Application of organocatalysts
Our research can be divided into 6 main parts:
-
Synthesis of cyclodextrin-cinchona organocatalysts containing thiourea or squaramide unit, and their application in asymmetric syntheses; catalyst recovery by OSN technique
-
Synthesis of piperidine-camphor sulfonamide derivatives, and their application in Michael additions
-
Michael addition reactions of N-Heterocycles
-
Optimization of aza-Markovnikov additions catalyzed by different cinchona derivatives
-
Synthesis of new axially chiral organocatalysts containing bis-1,1'-binaphthyl unit; attaching some of them to PBI membrane by click reaction
-
Immobilization of cinchona squaramide to polyglycidyl methacrylate support and its application in asymmetric synthesis
2020
-
Nagy, S.; Kisszékelyi, P.; Dargó, G.; Huszthy, P.; Kupai, J.: Új, cinkona alapú organokatalizátorok előállítása, alkalmazása és visszaforgatása
Magy. Kém. Foly. 2020, 126, 152–161.
DOI: 10.24100/MKF.2020.04.152
-
Kisszékelyi, P.; Nagy, S.; Fehér, Z.; Huszthy, P.; Kupai, J.: Membránszűréssel visszaforgatható homogén organokatalizátorok előállítása és alkalmazása
Magy. Kém. Foly. 2020, 126, 110–120.
DOI: 10.24100/MKF.2020.03.110
-
Kisszekelyi, P.; Nagy, S.; Fehér, Z.; Huszthy, P.; Kupai, J.: Membrane-Supported Recovery of Homogeneous Organocatalysts: A Review
Chemistry 2020, 2, 742–758.
DOI: 10.3390/chemistry2030048
-
Nagy, S.; Fehér, Z.; Kárpáti, L.; Bagi, P.; Kisszékelyi, P.; Koczka, B.; Huszthy, P.; Pukánszky, B.; Kupai, J.: Synthesis and applications of cinchona squaramide‐modified poly(glycidyl methacrylate) microspheres as recyclable polymer‐grafted enantioselective organocatalysts
Chem. Eur. J. 2020, accepted article (IF: 4.857 in 2019)
-
Kisszekelyi, P.; Hardian, R.; Vovusha, H.; Chen, B.; Zeng, X.; Schwingenschlogl, U.; Kupai, J.; Szekely G.: Selective Electrocatalytic Oxidation of Biomass-derived 5-Hydroxymethylfurfural to 2,5-Diformylfuran: From Mechanistic Investigations to Catalyst Recovery
ChemSusChem 2020, 13, 3127–3136. (IF: 7.962 in 2019)
DOI: 10.1002/cssc.202000453
2019
-
Nagy, S.; Fehér, Z.; Dargó, G.; Barabás, J.; Garádi, Z.; Mátravölgyi, B.; Kisszékelyi, P.; Dargó, Gy.; Huszthy, P.; Höltzl, T.; Balogh, G. T.; Kupai, J.: Comparison of Cinchona Catalysts Containing Ethyl or Vinyl or Ethynyl Group at Their Quinuclidine Ring
Materials 2019, 12, 3034 (IF: 3.057)
DOI: 10.3390/ma12183034
-
Nagy, S.; Dargó, G.; Kisszekelyi, P.; Fehér, Z.; Simon, A.; Barabás, J.; Höltzl, T.; Mátravölgyi, B.; Karpati, L.; Drahos, L.; Huszthy, P.; Kupai, J.: New enantiopure binaphthyl-cinchona thiosquaramides: synthesis and application for enantioselective organocatalysis
New J. Chem. 2019, 43, 5948-5959. (IF: 3.288)
DOI: 10.1039/C8NJ06451B
-
Kisszekelyi, P.; Alammar, A.; Kupai, J.; Huszthy, P.; Barabas, J.; Holtzl, T.; Szente, L.; Bawn, C.; Adams, R.; Szekely, G.: Asymmetric synthesis with cinchona-decorated cyclodextrin in a continuous-flow membrane reactor
J. Catal. 2019, 371, 255-261. (IF: 7.888)
DOI: 10.1016/j.jcat.2019.01.041
2018
-
Nagy, S.; Kisszékelyi, P.; Kupai, J.: Synthesis and Application of Thiosquaramides and Their Derivatives: A Review
Period. Polytech. Chem. Eng. 2018, 62, 467-475. (IF: 1.382)
DOI: 10.3311/PPch.12851
-
Kisszékelyi, P.; Nagy, S.; Tóth, B.; Zeller, B.; Hegedűs, L.; Mátravölgyi, B.; Grün, A.; Németh, T.; Huszthy, P.; Kupai, J.: Synthesis and recovery of pyridine- and piperidine-based camphorsulfonamide organocatalysts used for Michael addition reaction.
Period. Polytech. Chem. Eng. 2018, 62, 489-496. (IF: 1.382)
DOI: 10.3311/PPch.12719
-
Nagy, S; Fehér, Z.; Kisszékelyi, P.; Huszthy, P.; Kupai, J.: Cinchona derivatives as sustainable and recyclable homogeneous organocatalysts for aza-Markovnikov addition.
New J. Chem. 2018, 42, 8596-8602. (IF: 3.069)
DOI: 10.1039/C8NJ01277F
-
Didaskalou, C.; Kupai, J.; Cseri, L.; Barabas, J.; Vass, E.; Holtz, T.; Szekely, G.: Membrane-Grafted Asymmetric Organocatalyst for an Integrated Synthesis–Separation Platform.
ACS Catal. 2018, 8, 7430–7438. (IF: 12.221)
DOI: 10.1021/acscatal.8b01706
2017
-
Fődi, T.; Didaskalou, C.; Kupai, J.; Balogh, G. T.; Huszthy, P.; Szekely, G.:Nanofiltration-Enabled In Situ Solvent and Reagent Recycle for Sustainable Continuous-Flow Synthesis.
ChemSusChem 2017, 10, 3435-3444. (IF: 7.116)
DOI: 10.1002/cssc.201701120
-
Kupai, J.; Razali, M.; Buyuktiryaki, S.; Kecili, R.; Szekely, G.: Long-term stability and resuability of molecularly imprinted polymers
Polym. Chem. 2017, 8, 666–673. (IF: 5.375)
DOI: 10.1039/C6PY01853J
HIGHLY CITED PAPER (WEB OF SCIENCE)
As of September/October 2018, this highly cited paper received enough citations to place it in the top 1% of the academic field of Chemistry based on a highly cited threshold for the field and publication year. Data from Essential Science Indicators
2016
-
Kupai, J.; Kisszékelyi, P.; Rojik, E.; Dargó, G.; Hegedűs, L.; Bezzegh, D.; Maszler, P.; Szabó, L.; Németh, T.; Balogh, Gy. T.; Huszthy, P.: Synthesis and determination of pKa values of new enantiopure pyridino- and piperidino-18-crown-6 ethers, Arkivoc, 2016, iv, 130–151.
Arkivoc 2016, iv, 130–151. (IF: 1.031)
DOI: 10.3998/ark.5550190.p009.592
-
Fődi, T.; Kupai, J.; Túrós, G.; Németh, T.; Rojik, E.; Balogh, G. T., Huszthy, P.: Application of Flow
Chemistry to Macrocyclization of Crown Ethers.
J. Flow Chem. 2016, 6, 297–301.
DOI: 10.1556/1846.2016.00033
-
Cseri, L.; Fődi, T.; Kupai, J.; Balogh, G.; Garforth, A.; Szekely, G.: Membrane-assisted catalysis in
organic media.
Adv. Mater. Lett. 2016, 8, 1094-1124.
DOI: 10.5185/amlett.2017.1541
2015
-
Kupai J.; Rojik E.; Huszthy P.; Székely Gy.: Role of Chirality and Macroring in Imprinted Polymers with Enantiodiscriminative Power
ACS Appl. Mater. Interfaces 2015, 7, 9516–9525. (IF: 7.145)
DOI: 10.1021/acsami.5b00755
Cooperations
This subgroup is the part of the Supramolecular Chemistry Research Group at BUTE, Department of Organic Chemistry and Technology. Its group leader is: Peter Huszthy, PhD, DSc, Member of HAS.
Our main partners are:
-
Gyorgy Szekely, PhD, KAUST, Saudi and The University of Manchester, UK
-
Matyas Milen, PhD, Egis Pharmaceutical Plc.
-
Gyorgy T. Balogh, Gedeon Richter Pharmaceutical Plc.
-
Peter Abranyi-Balogh, PhD, HAS-Research Center
-
Bela Pukanszky, PhD, DSc, Member of HAS, BUTE, Department of Physical Chemistry and Material Science
-
Emília Csiszar, PhD, BUTE, Department of Physical Chemistry and Material Science
-
Bela Matravolgyi, PhD, BUTE, Department of Organic Chemistry and Technology
-
Tamas Hergert, PhD, BUTE, Department of Organic Chemistry and Technology
-
Tibor Holtzl, PhD, BUTE, Department of Inorganic and Analytical Chemistry
-
Viola Horvath, PhD, BUTE, Department of Inorganic and Analytical Chemistry
-
Andras Simon, PhD, BUTE, Department of Inorganic and Analytical Chemistry
-
Bela Koczka, PhD, BUTE, Department of Inorganic and Analytical Chemistry